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Introduction: Stress and lifestyle-related diseases such as hypertension, diabetes mellitus, obesity, and cardiovascular disorders have emerged as leading contributors to global morbidity and mortality. Chronic stress acts as both a precipitating and perpetuating factor in these conditions. Ayurveda, with its holistic philosophy, offers preventive and therapeutic modalities through Dinacharya (daily regimen), Ritucharya (seasonal regimen), Sadvritta (ethical lifestyle), Rasayana therapy, yoga, and meditation. Methods: A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, AYUSH Research Portal, and Google Scholar for studies published between 2000–2024. Ayurvedic classics including Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya were reviewed. Clinical trials, observational studies, systematic reviews, and experimental studies evaluating Ayurvedic interventions for stress and lifestyle diseases were included. Results: Ayurvedic concepts such as Manasika Doshas (Rajas and Tamas), Pragyaparadha (intellectual error), and Ojas depletion correlate strongly with modern psychoneuroimmunology. Evidence supports the role of Medhya Rasayanas (Brahmi, Ashwagandha, Mandukaparni, Shankhapushpi) in reducing stress and improving cognition. Lifestyle interventions like yoga, meditation, and pranayama demonstrate significant reductions in blood pressure, cortisol, HbA1c, and lipid levels. Preventive regimens like Dinacharya and Ritucharya enhance circadian balance, metabolic health, and resilience to stress. Discussion: Ayurveda provides a multidimensional strategy addressing mind, body, and behavior. Integrating Ayurvedic stress management into modern healthcare can reduce disease burden. However, further large-scale, high-quality clinical trials are needed. Conclusion: Ayurveda offers promising, evidence-based tools for managing stress and lifestyle diseases through preventive regimens, Rasayana therapies, and mind-body practices. Its integration into public health strategies could promote sustainable well-being.

KEYWORDS: Ayurveda, lifestyle diseases, Rasayana, stress management, yoga