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Introduction: Lifestyle disorders such as diabetes mellitus, hypertension, obesity, and cardiovascular diseases are increasing globally due to sedentary habits, poor diet, and stress. Ayurveda describes Vyadhi Kshamatva (immunity) as the inherent capacity of the body to resist diseases and maintain homeostasis. This review explores the relevance of Vyadhi Kshamatva in preventing and managing lifestyle disorders. Methods: A comprehensive literature review was carried out using Ayurvedic classical texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya), PubMed, Scopus, and Web of Science databases. Inclusion criteria were original research, review articles, and clinical studies on immunity, Ayurveda-based interventions, and lifestyle diseases published from 2000–2024. Exclusion criteria were non-peer-reviewed articles, case reports, and unrelated studies. Results: Ayurveda emphasizes Vyadhi Kshamatva as influenced by Ojas, Agni, Dosha balance, and Srotas integrity. Modern evidence supports this, linking immunity with gut microbiome, oxidative stress regulation, and metabolic health. Lifestyle modifications such as Dinacharya, Ritucharya, yoga, meditation, and Rasayana therapy enhance immune function. Several studies show the protective role of Ayurvedic herbs (e.g., Ashwagandha, Guduchi, Amalaki) in reducing the risk of diabetes, obesity, and cardiovascular dysfunction. Discussion: While Ayurveda offers a holistic model of immunity, modern science validates many of its principles through emerging fields like psychoneuroimmunology and epigenetics. However, clinical evidence integrating both systems is still limited. Conclusion: Vyadhi Kshamatva represents a dynamic framework that strengthens resilience against lifestyle disorders. Integrating Ayurvedic preventive strategies with modern lifestyle interventions may help reduce the global burden of chronic diseases.

KEYWORDS: Ayurveda, Immunity, Lifestyle disorders, Rasayana, Vyadhi Kshamatva